The most basic way to enter a reference is by manually typing it in. Click References menu / New Reference. Remember to enter multiple author names on separate lines. Press Tab to move between fields.
You can enter author names either last name first with a comma ("Smith, Jane") or first name first ("Jane Smith").
Tip: When entering a corporate or institutional author name like "Syracuse University" or "Centers for Disease Control", enter a comma after the name. This will prevent EndNote from inverting or abbreviating the name as it would for an individual author's.
Search the database via the web interface as you normally would. Select the references you want, then save or export them. Every database works a little differently but most databases can export to EndNote with these general steps:
For the databases that don't allow direct import, you can use EndNote's import filters to transfer the reference data into your EndNote library:
Google Scholar is a good tool for quickly finding articles. When using Google Scholar be sure to set your preferences allow for export to EndNote.
Use the gear to select scholar preferences:
Choose EndNote as your Bibliography Manager: